Initiating Clinical Trials: A Case Study of Intermittent Positive Pressure Breathing

Initiating Clinical Trials: A Case Study of Intermittent Positive Pressure Breathing

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Describes the events surrounding the decision by the National Heart and Lung Institute (NHLI) to issue a request for proposal (RFP) to conduct a multicenter randomized clinical trial comparing the efficacy of intermittent positive pressure breathing (IPPB) with compressor nebulizer therapy in treating patients with chronic obstructive pulmonary disease (COPD).